Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro.

نویسندگان

  • Andrew I Share
  • Khushali Patel
  • Cristina Nativi
  • Eun J Cho
  • Oscar Francesconi
  • Nathalie Busschaert
  • Philip A Gale
  • Stefano Roelens
  • Jonathan L Sessler
چکیده

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(-) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus in vitro.

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عنوان ژورنال:
  • Chemical communications

دوره 52 48  شماره 

صفحات  -

تاریخ انتشار 2016